Possible, but I can't understand creating an ongoing title for a character that seems to have literally been created for an "event". It'd be like creating a Pariah book or an Alexander Luthor book. It's conceptually possible, but reality says that not many of us were clamoring for this. I'll admit that an outlier, in my case, is Vibe. I think that the number of people looking forward to his revival may be in negative numbers, but I'm actually fairly interested after the first issue.
Lady Quark the series - you're right, doesn't work