I don't have a science-breaking point - I can handle any amount of what I'm going to call 'Magience' - but I do have a rationality breaking point. A recent-ish Eliezer Yudkowsky comment got me thinking about this:
An Idiot Plot is any plot that goes away if the characters stop being idiots. A Muggle Plot is any plot which dissolves in the presence of transhumanism and polyamory. That exact form is surprisingly common; e.g. from what I've heard, canon!Twilight has two major sources of conflict, Edward's belief that turning Bella into a vampire will remove her soul, and Bella waffling between Edward and Jacob. I didn't realize it until Baughn pointed it out, but S1 Nanoha - not that I've watched it, but I've read fanfictions - counts as a Muggle Plot because the entire story goes away if Precia accepts the pattern theory of identity.
Take Star Trek, for example. The central theme of Star Trek is (what they call) Logic vs. (what they call) Emotion. But rationality is about achieving your goals and for nearly everyone that will involve experiencing emotions like love and happiness. Thankfully, nothing in rationality says that you can't have emotions but the creators of Star Trek just don't understand that. To them, there is this thing called 'Logic,' which is given a totally different definition than the ordinary one and sometimes you have to put it aside because, dammit you green-blooded fool, the world just isn't Logical!
In order to find these themes interesting you have to not know about decision theory. Once you get that, the whole thing just evaporates.
Or LOST. The central theme of LOST is (what they call) Science vs (what they call) Faith. But the maths behind knowledge is probability theory, which allows you to describe a state of knowledge with numbers instead of words and tells you how confident you should be about a claim (if something has a probability of 0.74 then you should be 74% sure about it). If you buy a lottery ticket and the odds of winning are 1 in a million, it doesn't make any sense to say, 'Some times you've got to have faith, Jack!' because why did you decide to have faith in THAT ticket instead of the one of the other 999,999?
If I argue that it's one of those others instead, I have a 999,999 in a million chance of being right vs. your 1 in a million chance. I don't have 'Just as much faith as you,' it doesn't make any difference if, 'There are some things we're just not meant to know,' it won't in any way improve your odds if I'm not able to answer questions like, 'Why is there something rather than nothing?' or 'Fucking magnets! How do they work?' In order to find these themes interesting you have to not know about probability theory. Once you get that, the whole thing just evaporates.
More and more, I'm having a hard time enjoying this shit. I didn't watch Prometheus at all and never will because I knew it would be full of people asking Muggle questions like, 'Can a machine be alive?!' as if they were profound mysteries. It's like, it would never even occur
to you to write something like that in the first place if you weren't horribly confused
about some really important topics. And once you know this stuff, you can never go back to not
knowing without some kind of, on-balance regrettable, head injury. So, I dunno. Right now, I've just settled for looking for stupid shit that entertains me instead of stupid shit that doesn't even do that. There's no escaping it.