It's nothing the Celestials haven't been doing for a long time.
Have you been reading Avengers? The Builders apparently work with the underlying structure of the Universe, and not with just messing around with other lifeforms.
At the end of the day this Avengers lineup is too powerful and will have to be broken up at the end of this event.
Infinity sounds more and more like a setup event as it goes on. It feels like Hickman is using Infinity to ratchet up his ongoing storylines in Avengers and New Avengers, rather than concluding them all.
It didn't sound like the book would be shying away from the cosmic stuff following Infinity. There's supposed to be a little reshuffling of the team after Infinity, but I suspect that will involve something more on the lines of SpOck getting fired and maybe Wolverine leaving.
As far as cosmic teams go I'll stick with GotG and the Nova corps when they finally bring Richard Rider back. The only thing that might work would be the Inhumans in space.
Which is you're loss, as Hickman's work on Avengers has been awesome.