Going 1st out of the gate is the BEST thing you can do -- the only danger is if the A/V fouls up, which they won't have had time to be sure of for the first talk (I speak from experience). But these days it is not as big of a deal... back when it happened to me PPT was just getting started and not everything "just worked" the way it does now (plug and play was a concept that had not yet been fully realized). These days there should be no issues.
But the HUGE advantage of going 1st is that then it's OVER WITH and you can just enjoy the conference.
I had the unpleasant experience this year at a science conference of going in the LAST SESSION of the conference. Sucked for multiple reasons, but the main one was that I could never just relax and enjoy the other talks fully because my brain kept rehearsing what I was going to say, non-stop, for 4 days.
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