Spider-Man's uncle being dead isn't apparent in every issue of Spider-Man, doesn't mean it's irrelevant.
The issue should stand on its own and it doesn't. It is interesting back story, and could be a reason to look into the history of the book. It certainly is one thing that leads to the dynamics in the book, but there is nothing about it mentioned in this book. Sad, given that it is 13 issues in and the "interesting plot device" can't even be mentioned.
This was a mediocre comic by a strong creative team. Which seems to pretty much define marvel currently.
Pull list: Afterlife with Archie, Bodies, Chilling Adventures of Sabrina, Coffin Hill, Dead Boy Detectives, The Fade Out, The Goon, Harley Quinn, Hinterkind, Iron Fist: The Living Weapon,The Maxx Maximized, Miracleman, Ms. Marvel, Multiversity, Rasputin, Rocket Raccoon, Sandman: Overture, Silver Surfer, The Walking Dead